Høgdall C K, Christiansen M, Brihmer C
Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark.
Acta Obstet Gynecol Scand. 1995 Mar;74(3):203-7. doi: 10.3109/00016349509008939.
To clarify the impact of the presence of pelvic inflammatory disease (PID) and activation of the acute phase response on the serum level of tetranectin (Se-TN), a potential new tumor marker for ovarian cancer.
The study group consisted of 70 patients with a laparoscopically verified PID and 47 healthy female controls.
Lower Se-TN levels were found for the PID group compared to the control group (p < 0.0001). It was not possible to relate the decreases in Se-TN levels to any distinct bacterial strain. Neither was it possible to find any correlation between Se-TN and severity of PID (p = 0.5). A significant positive correlation was found between Se-TN and ALB (p < 0.001). A just significant negative correlation was found between Se-TN and C-reactive protein (CRP) (p = 0.04), while no correlation was found with any of the other acute phase reactants. Highly significant correlations were found between all the acute phase reactants and grade of PID.
A slight, but significant reduction in Se-TN was found in PID patients. The decrease was minor compared to the reported findings of very low Se-TN levels for ovarian cancer patients. However, the finding is important in the assessment of TN used as a potential screening marker for ovarian cancer, or as a diagnostic tool for pelvic tumors. Furthermore, Se-TN does not seem to behave as a negative acute phase reactant.
阐明盆腔炎（PID）的存在及急性期反应的激活对四连蛋白（血清四连蛋白，Se-TN）水平的影响，四连蛋白是一种潜在的新型卵巢癌肿瘤标志物。
研究组由70例经腹腔镜检查证实患有PID的患者和47例健康女性对照组成。
与对照组相比，PID组的Se-TN水平较低（p < 0.0001）。无法将Se-TN水平的降低与任何特定细菌菌株相关联。也无法在Se-TN与PID严重程度之间找到任何相关性（p = 0.5）。发现Se-TN与ALB之间存在显著正相关（p < 0.001）。发现Se-TN与C反应蛋白（CRP）之间存在刚刚显著的负相关（p = 0.04），而与任何其他急性期反应物均未发现相关性。在所有急性期反应物与PID分级之间发现了高度显著的相关性。
在PID患者中发现Se-TN有轻微但显著的降低。与报道的卵巢癌患者极低的Se-TN水平相比，这种降低幅度较小。然而，这一发现对于评估TN作为卵巢癌潜在筛查标志物或盆腔肿瘤诊断工具具有重要意义。此外，Se-TN似乎并非作为负急性期反应物。
