Johnson R N, Maffeo C J, Mann J D, Butler A B, Bass N H
TIT J Life Sci. 1978;8(3-4):79-92.
A comparative model of the cerebrospinal fluid (CSF) system in rat, dog and man was derived from manometric data using low volume, short duration infusions into the subarchanoid space in order to describe the mechanisms governing intracranial pressure dynamics. The mathematical model indicates that steady-state elevations of intracranial pressure are regulated primarily by a nonlinear, pressure dependent outflow resistance to CSF reabsorption. While the form of the resistance relationship is similar for the three species tested, differences in the magnitude of CSF outflow parameters are apparent. Model stimulation on a digital computer suggests that parameter changes within the resistance relationship can have a profound effect on the intracranial pressure. In contrast, intracranial compliance acts only to buffer transient changes in volume prior to the establishment of steady-state CSF pressures.
通过向大鼠、狗和人的蛛网膜下腔进行小容量、短时间输注的测压数据，得出了脑脊液（CSF）系统的比较模型，以描述颅内压动态变化的调控机制。数学模型表明，颅内压的稳态升高主要由脑脊液重吸收的非线性、压力依赖性流出阻力调节。虽然在所测试的三种物种中阻力关系的形式相似，但脑脊液流出参数的大小存在明显差异。在数字计算机上进行的模型模拟表明，阻力关系内的参数变化可对颅内压产生深远影响。相比之下，颅内顺应性仅在脑脊液压力达到稳态之前缓冲体积的瞬时变化。
