Mann J D, Butler A B, Rosenthal J E, Maffeo C J, Johnson R N, Bass N H
Ann Neurol. 1978 Feb;3(2):156-65. doi: 10.1002/ana.410030212.
Intracranial resistance and compliance were assessed in the cerebrospinal fluid system of rat, dog, and man by means of low-volume, short-duration infusions of artificial CSF into the subarachnoid space. A family of pressure/time response curves was obtained for each species: at low flow rates, steady-state pressure elevations were associated with normal neurological function; at high flow rates, rapid linear pressure elevations were associated with marked neurological dysfunction. From these curves a mathematical model was developed which describes transport and pressure-dependent valvelike characteristics of the CSF outflow resistance. This resistance shows a progressive phylogenetic change in rat, dog, and man which increasingly enhances the species' abilities to vent fluid from the intracranial cavity into the venous circulation. Arachnoid villi appear to be the major structures modulating sustained, nonlethal elevations of intracranial pressure.
通过向大鼠、狗和人的蛛网膜下腔低容量、短时间输注人工脑脊液，对脑脊液系统中的颅内阻力和顺应性进行了评估。为每个物种获得了一组压力/时间响应曲线：在低流速下，稳态压力升高与正常神经功能相关；在高流速下，快速线性压力升高与明显的神经功能障碍相关。从这些曲线中建立了一个数学模型，该模型描述了脑脊液流出阻力的传输和压力依赖性瓣膜样特征。这种阻力在大鼠、狗和人中显示出渐进的系统发育变化，越来越增强了物种将液体从颅内腔排入静脉循环的能力。蛛网膜绒毛似乎是调节颅内压持续、非致命性升高的主要结构。
