Bossens M M, Van Straalen J P, De Reijke T M, Kurth K H, Sanders G T
Department of Urology, Amsterdam, The Netherlands.
Eur J Cancer. 1995;31A(5):682-5. doi: 10.1016/0959-8049(95)00016-c.
Kinetics of prostate-specific antigen (PSA) were investigated after manipulation of the prostate in two groups of patients: those treated with digital rectal examination (DRE), and those with needle biopsy. 8 patients had serial PSA measurements to study the effect of DRE (group 1). 7 of 8 patients had PSA baseline values < 10 ng/ml. Blood samples were taken at 1 min, 30 min, 1, 3, 6, 12 and 24 h after DRE. Some patients were further monitored for 5 days with one blood sample taken at the same time each day. Statistically significant increased PSA levels were found after DRE (P < 0.001). Maximal increase was 70%. In most patients, peak levels were found between 30 and 60 min after DRE. Based on the results, it is concluded that after DRE it is prudent to wait 3 days before PSA is determined. 7 patients had serial PSA measurements after transrectal prostate needle biopsy (group 2). PSA sampling was similar as in the previous group. All patients had increased PSA levels after biopsy (range 1.3-9.5-fold). After 5 days, only 2 of 7 patients had returned to baseline levels. We conclude that biopsies of the prostate induce an important and long-lasting PSA elevation.
在两组患者的前列腺受到刺激后，研究了前列腺特异性抗原（PSA）的动力学：接受直肠指检（DRE）的患者和接受穿刺活检的患者。8名患者进行了连续的PSA测量，以研究DRE的影响（第1组）。8名患者中有7名的PSA基线值<10 ng/ml。在DRE后1分钟、30分钟、1小时、3小时、6小时、12小时和24小时采集血样。一些患者进一步监测5天，每天在同一时间采集一份血样。DRE后发现PSA水平有统计学意义的升高（P<0.001）。最大增幅为70%。在大多数患者中，DRE后30至60分钟出现峰值水平。根据结果得出结论，DRE后谨慎起见应等待3天再测定PSA。7名患者在经直肠前列腺穿刺活检后进行了连续的PSA测量（第2组）。PSA采样与前一组相似。所有患者活检后PSA水平均升高（范围为1.3至9.5倍）。5天后，7名患者中只有2名恢复到基线水平。我们得出结论，前列腺活检会引起重要且持久的PSA升高。
