Breul J, Binder K, Block T, Hartung R
Department of Urology, Technical University Munich, Klinikum rechts der Isar, FRG.
Eur Urol. 1992;21(3):195-9. doi: 10.1159/000474837.
Prostate-specific antigen (PSA) is used for screening and follow-up of patients with prostate cancer. The effect of certain diagnostic procedures on PSA serum levels is not well defined. Therefore, the effect of digital rectal examination (DRE) on PSA serum levels was investigated. No significant difference was observed in PSA values before and after DRE when blood samples were taken 1-3 min after palpation of the prostate. Kinetic studies demonstrated a significant increase in PSA values up to the factor 3.2 in 14 of 19 patients 2-6 h after DRE. In 9 of 14 cases, PSA was within the initial range 24 h after DRE. That means that a urologist is allowed to take blood samples for the determination of PSA at least within 3 min after palpating a suspicious prostate without getting false-positive results.
前列腺特异性抗原（PSA）用于前列腺癌患者的筛查和随访。某些诊断程序对PSA血清水平的影响尚不明确。因此，研究了直肠指检（DRE）对PSA血清水平的影响。当在前列腺触诊后1 - 3分钟采集血样时，DRE前后的PSA值未观察到显著差异。动力学研究表明，19例患者中有14例在DRE后2 - 6小时PSA值显著升高，最高达3.2倍。在14例中的9例中，DRE后24小时PSA恢复到初始范围。这意味着泌尿科医生在触诊可疑前列腺后至少3分钟内采集血样测定PSA不会得到假阳性结果。
