• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs.

作者信息

Lam E, Martin M, Wiederrecht G

机构信息

Department of Immunology Research, Merck Research Laboratories, Rahway, NJ 07065, USA.

出版信息

Gene. 1995 Jul 28;160(2):297-302. doi: 10.1016/0378-1119(95)00216-s.

DOI:10.1016/0378-1119(95)00216-s
PMID:7543869
Abstract

Reduced-stringency PCR was used to isolate a cDNA encoding a novel human FK506-binding protein (FKBP) homolog. The encoded 38-kDa protein (FKBPr38) contains at its N-terminus a domain that is 33% identical to FKBP12. FKBPr38 is a member of a subclass of immunophilins, whose other members include FKBP52 and CyP40 (cyclophilin 40), that contain a three-unit tetratricopeptide repeat (TPR). In addition, FKBPr38 contains a consensus leucine-zipper repeat. The presence of the TPR domain and leucine zipper suggest that FKBPr38 may form homo-multimers or interact with other, as yet unidentified, proteins.

摘要

相似文献

1
Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs.
Gene. 1995 Jul 28;160(2):297-302. doi: 10.1016/0378-1119(95)00216-s.
2
A novel plant peptidyl-prolyl-cis-trans-isomerase (PPIase): cDNA cloning, structural analysis, enzymatic activity and expression.一种新型植物肽基脯氨酰顺反异构酶（PPIase）：cDNA克隆、结构分析、酶活性及表达
Plant Mol Biol. 1996 Nov;32(3):493-504. doi: 10.1007/BF00019101.
3
Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.人FKBP52的表达与特性研究，FKBP52是一种与90 kDa热休克蛋白相关的亲免素，也是类固醇受体复合物的一个组成部分。
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10974-8. doi: 10.1073/pnas.89.22.10974.
4
FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex.FKBP46，一种新型的Sf9昆虫细胞核亲免素，可形成一种蛋白激酶复合物。
J Biol Chem. 1994 Dec 9;269(49):30828-34.
5
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.热休克蛋白90辅助伴侣亲环素40与热休克同源蛋白70的相互作用。
Cell Stress Chaperones. 2004 Summer;9(2):167-81. doi: 10.1379/csc-26r.1.
6
FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition.FKBP51，一种新型的能够抑制钙调神经磷酸酶的T细胞特异性亲免素。
Mol Cell Biol. 1995 Aug;15(8):4395-402. doi: 10.1128/MCB.15.8.4395.
7
The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59).未激活的雌激素受体的亲环蛋白成分包含一个四肽重复结构域，且与p59（FKBP59）具有同源性。
J Biol Chem. 1993 Jun 25;268(18):13187-92.
8
Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.一种与人类FK506结合蛋白12kDa（hFKBP - 12）高度同源的新型人类基因的分子克隆、表达及两种可变剪接转录本的特性分析
Biochem Biophys Res Commun. 1994 Apr 29;200(2):836-43. doi: 10.1006/bbrc.1994.1527.
9
Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin.编码人T细胞FK506结合蛋白的互补DNA，一种不同于亲环蛋白的肽基脯氨酰顺反异构酶。
Proc Natl Acad Sci U S A. 1990 Jul;87(14):5440-3. doi: 10.1073/pnas.87.14.5440.
10
The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and hop is located in the dimerization domain of Hsp90.类固醇受体相关亲免素和HOP的常见四肽重复序列受体位点位于Hsp90的二聚化结构域中。
J Biol Chem. 1999 Jan 29;274(5):2682-9. doi: 10.1074/jbc.274.5.2682.

引用本文的文献

1
FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres.FKBP38 调节 GBM 神经球的自我更新和存活。
Cells. 2023 Nov 2;12(21):2562. doi: 10.3390/cells12212562.
2
Unraveling the complex genetics of neural tube defects: From biological models to human genomics and back.揭开神经管缺陷的复杂遗传学之谜：从生物模型到人类基因组学再到生物模型。
Genesis. 2021 Nov;59(11):e23459. doi: 10.1002/dvg.23459. Epub 2021 Oct 29.
3
Regulation of PRKN-independent mitophagy.PRKN 非依赖性线粒体自噬的调控。
Autophagy. 2022 Jan;18(1):24-39. doi: 10.1080/15548627.2021.1888244. Epub 2021 Feb 25.
4
FKBP8 variants are risk factors for spina bifida.FKBP8 变体是脊柱裂的风险因素。
Hum Mol Genet. 2020 Nov 4;29(18):3132-3144. doi: 10.1093/hmg/ddaa211.
5
FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane.FKBP8 增强 CLC-1 氯离子通道在质膜上的蛋白稳定性。
Int J Mol Sci. 2018 Nov 28;19(12):3783. doi: 10.3390/ijms19123783.
6
Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation.信号肽酶通过促进 FKBP8 降解促进肿瘤进展。
Oncogene. 2019 Mar;38(10):1688-1701. doi: 10.1038/s41388-018-0539-y. Epub 2018 Oct 22.
7
FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice.FKBP8 通过防止蛋白质错误折叠和内质网相关细胞凋亡在小鼠中积累，从而保护心脏免受血流动力应激。
J Mol Cell Cardiol. 2018 Jan;114:93-104. doi: 10.1016/j.yjmcc.2017.11.004. Epub 2017 Nov 10.
8
The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90.FKBP38与热休克蛋白90的MEEVD四肽重复序列结合基序形成复合物的结构。
PLoS One. 2017 Mar 9;12(3):e0173543. doi: 10.1371/journal.pone.0173543. eCollection 2017.
9
FK506-Binding Proteins and Their Diverse Functions.FK506结合蛋白及其多样功能。
Curr Mol Pharmacol. 2015;9(1):48-65. doi: 10.2174/1874467208666150519113541.
10
Direct Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells.绒山羊胎儿成纤维细胞中脑富集同源蛋白与FK506结合蛋白38之间的直接相互作用
Asian-Australas J Anim Sci. 2014 Dec;27(12):1671-7. doi: 10.5713/ajas.2014.14145.