Malins A F
Lancet. 1978 Feb 25;1(8061):413-5. doi: 10.1016/s0140-6736(78)91203-5.
5 patients developed pulmonary oedema after retrograde femoral arteriography under general anesthesia. Because of the haemodynamic changes associated with radiographic contrast media, a good preoperative cardiological assessment is essential. The volume and nature of the contrast media injected and any other fluid administered should be carefully monitored. There is no apparent safe maximum dose of radiographic contrast media, but this work suggests that for 'Conray 420' (sodium iothalamate 70% w/v) a total dose should be less than 200 ml in a fit patient. The dose should be substantially smaller in patients with a history of evidence of myocardial infarction, myocardial insufficiency, myocardial ischaemia, or hypertension.
5例患者在全身麻醉下行逆行股动脉造影后发生肺水肿。由于与放射造影剂相关的血流动力学变化，术前进行良好的心脏评估至关重要。应仔细监测注入的造影剂和任何其他给予的液体的量及性质。目前尚无明显安全的造影剂最大剂量，但这项研究表明，对于“康瑞420”（70%w/v碘他拉酸钠），健康患者的总剂量应小于200ml。有心肌梗死、心肌功能不全、心肌缺血或高血压病史的患者，剂量应大幅减少。
