Fischer W
Acta Biol Med Ger. 1978;37(11-12):1681-9.
A very important cause of the spike adaptation in the slowly adapting stretch receptor neuron (SN1) is the Na-K ionic pump. An increasing inhibition of the ionic pump, produced by gradual reduction of the external K+-concentration or application of rising doses of ouabain, is correlated with an adequate diminution of frequency decay. But even high concentrations of ouabain (10(-3) -- 5 . 10(-3) M) can not completely abolish the spike adaptation. Immediately after the onset of a current step the impulse frequency still declines. In agreement with these findings the gain in the Bode diagram shows a maximum further on. The spike adaptation in the rapidly adapting neuron (SN2) can only in a smaller part be attributed to the action of the ionic pump. Application of ouabain causes in the SN2, contrary to SN1, only a low depolarization of the membrane potential. The decay of impulse frequency is considerably diminished but a long lasting nearly stationary discharge like in the SN1 can never be observed.
慢适应牵张感受器神经元（SN1）中峰适应的一个非常重要的原因是钠钾离子泵。通过逐渐降低细胞外钾离子浓度或应用剂量不断增加的哇巴因所产生的离子泵抑制作用增强，与频率衰减的适度减小相关。但即使是高浓度的哇巴因（10⁻³ - 5×10⁻³ M）也不能完全消除峰适应。在电流阶跃开始后，冲动频率仍会立即下降。与这些发现一致，波特图中的增益进一步显示出最大值。快速适应神经元（SN2）中的峰适应仅在较小程度上可归因于离子泵的作用。与SN1相反，在SN2中应用哇巴因只会引起膜电位的低程度去极化。冲动频率的衰减显著减小，但从未观察到像SN1中那样持久的近乎稳定的放电。
