Kobayasi T, Gniadecki R, Serup J
Department of Dermatology, University of Copenhagen, Rigshospitalet, Denmark.
Acta Derm Venereol. 1995 May;75(3):222-7. doi: 10.2340/0001555575222227.
A new highly potent analogue (KH-1060) of vitamin D3 has been recently shown to stimulate the growth and differentiation of keratinocytes. This study was intended to determine the effects of this new analogue on epidermis at the ultrastructural level. KH-1060 was applied topically on the backs of hairless mice for 4 weeks; the skin was then studied by routine electron microscopy. The effects were compared with those of betamethasone-17-valerate and with concomitant treatment of KH-1060 following betamethasone. KH-1060 stimulated normal function of keratinocytes and formed a thick epidermis. The ultrastructure of the thick epidermis represents an enhanced normal process of keratinization and proliferation. Moreover, KH-1060 diminished the atrophogenic effects of betamethasone.
最近研究表明，一种新型高效维生素D3类似物（KH - 1060）可刺激角质形成细胞的生长和分化。本研究旨在从超微结构层面确定这种新型类似物对表皮的影响。将KH - 1060局部涂抹于无毛小鼠背部4周；然后通过常规电子显微镜对皮肤进行研究。将这些影响与倍他米松17 - 戊酸酯的影响以及倍他米松之后联合使用KH - 1060的影响进行比较。KH - 1060刺激角质形成细胞的正常功能并形成厚表皮。厚表皮的超微结构代表角质化和增殖的正常过程增强。此外，KH - 1060减轻了倍他米松的致萎缩作用。
