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脑和肝脏中线粒体定位的一氧化氮合酶的免疫细胞化学证据。

Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver.

作者信息

Bates T E, Loesch A, Burnstock G, Clark J B

机构信息

Department of Neurochemistry, University of London, Queen Square, England.

出版信息

Biochem Biophys Res Commun. 1995 Aug 24;213(3):896-900. doi: 10.1006/bbrc.1995.2213.

DOI:10.1006/bbrc.1995.2213
PMID:7544582
Abstract

In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in non-synaptosomal rat brain mitochondria and rat liver mitochondria, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that nitric oxide synthase located in mitochondria is involved in the regulation of mitochondrial oxidative phosphorylation is discussed.

摘要

在本文中,我们使用针对一氧化氮合酶内皮形式的单克隆抗体,展示了非突触体大鼠脑线粒体和大鼠肝线粒体中一氧化氮合酶的免疫细胞化学定位。本文还讨论了位于线粒体中的一氧化氮合酶参与线粒体氧化磷酸化调节的可能性。

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