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曲古抑菌素-Bs的亲脂性对离子通道形成及儿茶酚胺释放活性的影响。

Effect of lipophilicity of trichosporin-Bs on ion-channel formation and catecholamine-releasing activity.

作者信息

Nagaoka Y, Iida A, Kambara T, Tachikawa E, Asami K, Fujita T

机构信息

Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

出版信息

Biol Pharm Bull. 1995 Apr;18(4):640-2. doi: 10.1248/bpb.18.640.

DOI:10.1248/bpb.18.640
PMID:7544662
Abstract

A series of peptaibols, trichosporin (TS) -Bs, induced voltage-activated conductance in lipid bilayer membranes and catecholamine secretion from bovine adrenal chromaffin cells. The order of activities is the same as that of the lipophilicity rank of TS-Bs derived from the reversed-phase HPLC capacity factors.

摘要

一系列的短肽抗生素,即曲霉肽(TS)-Bs,可在脂质双层膜中诱导电压激活电导,并促进牛肾上腺嗜铬细胞分泌儿茶酚胺。其活性顺序与源自反相高效液相色谱容量因子的TS-Bs的亲脂性排名顺序相同。

相似文献

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Effect of lipophilicity of trichosporin-Bs on ion-channel formation and catecholamine-releasing activity.曲古抑菌素-Bs的亲脂性对离子通道形成及儿茶酚胺释放活性的影响。
Biol Pharm Bull. 1995 Apr;18(4):640-2. doi: 10.1248/bpb.18.640.
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Role of proline residue in the channel-forming and catecholamine-releasing activities of the peptaibol, trichosporin-B-VIa.
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Chem Biodivers. 2013 May;10(5):787-812. doi: 10.1002/cbdv.201200339.
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Hypopulvins, novel peptaibiotics from the polyporicolous fungus Hypocrea pulvinata, are produced during infection of its natural hosts.Hypopulvins 是一种新型的肽类抗生素,来源于多孔菌科的 Hypocrea pulvinata 真菌,在其天然宿主感染时产生。
Fungal Biol. 2012 Dec;116(12):1219-1231. doi: 10.1016/j.funbio.2012.10.003. Epub 2012 Oct 26.