Nagaoka Y, Iida A, Kambara T, Tachikawa E, Asami K, Fujita T
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Biol Pharm Bull. 1995 Apr;18(4):640-2. doi: 10.1248/bpb.18.640.
A series of peptaibols, trichosporin (TS) -Bs, induced voltage-activated conductance in lipid bilayer membranes and catecholamine secretion from bovine adrenal chromaffin cells. The order of activities is the same as that of the lipophilicity rank of TS-Bs derived from the reversed-phase HPLC capacity factors.
一系列的短肽抗生素,即曲霉肽(TS)-Bs,可在脂质双层膜中诱导电压激活电导,并促进牛肾上腺嗜铬细胞分泌儿茶酚胺。其活性顺序与源自反相高效液相色谱容量因子的TS-Bs的亲脂性排名顺序相同。