László K, Juszkó J, Bálint P
Acta Physiol Acad Sci Hung. 1978;52(1):71-86.
Renal functional parameters were investigated prior to and following release of 24 hr unilateral ureteral ligation (UUL). In the obstructd kidney renal blood flow (RBF) and glomerular filtration rate (GFR) decreased to about 50% and 14%, respectively, as compared to normal controls. Relief of the obstruction did not cause any change in renal haemodynamic parameters in the ligated kidney. Urine flow rate and urine osmolality in the previously obstructed kidney were decreased, the excreted fraction of filtered sodium increased as compared to the undisturbed kidney. The excretory lesion of the obstructed kidney is due to arteriolar, presumably preglomerular, vasoconstriction. Radioactive microspheres revealed that the decrease of RBF in the obstructed kidney was caused by diminished perfusion of the outer cortical zones, while blood flow to the inner cortical zones was unaltered. Fractional flow to the outer cortex was decreased, that to the inner cortex increased as compared with normal controls. In the undisturbed kidney there was a shifting of flow from the outer towards the inner cortex, while total blood flow remained unaltered.
在单侧输尿管结扎（UUL）24小时前后对肾功能参数进行了研究。与正常对照组相比，梗阻肾脏的肾血流量（RBF）和肾小球滤过率（GFR）分别下降至约50%和14%。梗阻解除后，结扎肾脏的肾血流动力学参数未发生任何变化。之前梗阻肾脏的尿流率和尿渗透压降低，与未受干扰的肾脏相比，滤过钠的排泄分数增加。梗阻肾脏的排泄损害是由于小动脉（可能是肾小球前）血管收缩所致。放射性微球显示，梗阻肾脏RBF的降低是由于外皮质区灌注减少，而内皮质区血流未改变。与正常对照组相比，外皮质的分流分数降低，内皮质的分流分数增加。在未受干扰的肾脏中，血流从外皮质向内皮质转移，而总血流量保持不变。
