Sugita T, Matsunaga K, Kobayashi H, Horikawa S, Suzuki Y, Nishiyama H, Maekawa N, Furuta H, Inui H, Fujimoto H
Dept. of Respiratory Medicine, Japanese Red Cross Society Wakayama Medical Center.
Gan To Kagaku Ryoho. 1995 Aug;22(9):1203-7.
We studied the efficacy of intrapleural administration of bleomycin for the management of malignant pleural effusions of non-small cell lung cancer in 24 cases. Bleomycin 60 mg was administered into the pleural space after tube drainage. If the effusion continued, one additional dose was given. The efficacy was seen in 18 cases (75%). The main adverse drug reaction was transient fever among others. There was little toxicity and no cases of pulmonary fibrosis. Intrapleural administration of bleomycin is useful in management of malignant pleural effusions.
我们研究了24例非小细胞肺癌恶性胸腔积液患者胸腔内注射博来霉素的疗效。在胸腔闭式引流后，向胸腔内注入60毫克博来霉素。如果积液持续存在，则再追加一剂。18例（75%）患者有疗效。主要的药物不良反应是短暂发热等。毒性很小，无肺纤维化病例。胸腔内注射博来霉素对恶性胸腔积液的治疗有效。
