Ocejo-Vinyals J Gonzalo, Gonzalez-Gay Miguel A, Fernández-Viña Marcelo A, Cantos-Mansilla Juan, Vilanova Iosune, Blanco Ricardo, González-López Marcos A
Department of Immunology, Hospital Universitario Marqués de Valdecilla. Avda. de Valdecilla s/n, 39008 Santander, Cantabria, Spain.
Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, IDIVAL, 39008 Santander, Cantabria, Spain.
J Clin Med. 2020 Sep 25;9(10):3095. doi: 10.3390/jcm9103095.
Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease of the hair follicle typically presenting recurrent, painful, and inflamed lesions on the inverse areas of the body. Although its pathogenesis remains unknown, the immune system appears to play a potential role. To date, two previous studies have not found any association between the Human Leukocyte Antigen system (HLA) and HS. In this study we analyzed the , ; and , - and allele distribution in 106 HS patients and 262 healthy controls from a Caucasian population in Cantabria (northern Spain). *29 and *50 were significantly more common in HS patients and *30 and *37 in controls, but these associations disappeared after statistical correction. *07, *02, and *02 were significantly more common in controls ( 0.026, 0.0012, and 0.0005, respectively) and the HLA allele *03:01 was significantly more common in HS patients ( 0.00007) after the Bonferroni correction. The haplotype was significantly more common in controls ( < 0.0005). This is the first study showing an association between HLA-class II and HS. Our results suggest that HLA-II alleles (*07, *02, *02, and *03:01) and the *07*02*02 haplotype could influence resistance or susceptibility to HS.
化脓性汗腺炎（HS）是一种毛囊的慢性炎性皮肤病，通常在身体的易摩擦部位出现反复发作的、疼痛性的炎性皮损。尽管其发病机制尚不清楚，但免疫系统似乎发挥着潜在作用。迄今为止，此前的两项研究未发现人类白细胞抗原系统（HLA）与HS之间存在任何关联。在本研究中，我们分析了来自西班牙北部坎塔布里亚白种人群的106例HS患者和262例健康对照中 、 ；以及 、 -和 等位基因的分布情况。29和50在HS患者中显著更常见，30和37在对照中更常见，但经统计学校正后这些关联消失。07、02和02在对照中显著更常见（分别为P = 0.026、P = 0.0012和P = 0.0005），经Bonferroni校正后，HLA等位基因03:01在HS患者中显著更常见（P = 0.00007）。 单倍型在对照中显著更常见（P < 0.0005）。这是第一项显示HLA - II类与HS之间存在关联的研究。我们的结果表明，HLA - II类等位基因（*07、02、02和03:01）以及07*02*02单倍型可能影响对HS的抵抗力或易感性。
