Yang H B, Hsu P I, Lee J C, Chan S H, Lin X Z, Chow N H
Department of Pathology, National Cheng Kung University, Tainan, Taiwan, Republic of China.
J Surg Oncol. 1995 Sep;60(1):35-40. doi: 10.1002/jso.2930600108.
To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal colonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non-neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma-carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal-appearing mucosae.
为了研究铁蛋白（FRN）表达的生物学意义，我们对正常结肠黏膜（n = 8）、腺瘤（n = 88）和结直肠癌（n = 104）进行了一项回顾性免疫组织化学研究。FRN存在于正常结肠黏膜隐窝底部的一些上皮细胞中。在26例（29.5%）腺瘤和54例（51.9%）腺癌中发现了显著的FRN细胞质染色。癌细胞中FRN的表达比例高于腺瘤或非肿瘤性黏膜中的细胞（P < 0.001）。FRN的表达与发育异常程度（P = 0.039）和腺瘤的远端位置（P = 0.013）呈正相关。FRN表达倾向于与肿瘤大小相关（P = 0.083），但在腺瘤的组织学类型之间未观察到实质性差异（P = 0.754）。结果表明，细胞质FRN表达与细胞增殖有关。增殖指数在腺瘤 - 癌序列中显示出显著差异。有必要进一步研究以阐明FRN在肿瘤细胞和外观正常黏膜中表达的临床意义。
