Degling L, Stjärnkvist P
Division of Pharmacy, Medical Products Agency, Uppsala, Sweden.
Vaccine. 1995 May;13(7):629-36. doi: 10.1016/0264-410x(94)00031-h.
The adjuvant effect of polyacryl starch microparticles was examined in mice using covalently coupled human serum albumin as a model antigen. Mice were immunized using different administration routes and the humoral and cellular immune responses were followed. The intraperitoneal immunizations gave the strongest humoral immune response, almost as high as with Freund's Complete Adjuvant (FCA), and the response after intravenous and intramuscular immunizations were somewhat lower. The delayed type hypersensitivity response was, after intramuscular immunization, about the same as after intraperitoneal immunizations with FCA. The results shows that polyacryl starch microparticles is a promising candidate for a new adjuvant for human use.
使用共价偶联的人血清白蛋白作为模型抗原，在小鼠中检测了聚丙烯酸淀粉微粒的佐剂效应。采用不同给药途径对小鼠进行免疫，并跟踪其体液免疫和细胞免疫反应。腹腔内免疫产生了最强的体液免疫反应，几乎与弗氏完全佐剂（FCA）相当，静脉内和肌肉内免疫后的反应略低。肌肉内免疫后的迟发型超敏反应与腹腔内注射FCA后的反应大致相同。结果表明，聚丙烯酸淀粉微粒是一种有前景的新型人用佐剂候选物。
