Yang Y C, Yin T
Department of Medicine (Hematology/Oncology), Indiana University Schoolof Medicine, Indianapolis 46202, USA.
Ann N Y Acad Sci. 1995 Jul 21;762:31-40; discussion 40-1. doi: 10.1111/j.1749-6632.1995.tb32312.x.
IL-11 is a multifunctional cytokine biologically related to IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic factor (CNTF). It has been shown that these cytokines can utilize common signal transducer, gp130. We have demonstrated that Jak tyrosine kinases, MAP kinases and pp90rsk are highly activated by IL-11 and related cytokines. In addition, we have identified pp90rsk as one of the H7 sensitive protein kinases critical for primary response gene expression induced by IL-11. Furthermore, activation of 3CH134 (a MAP kinase phosphatase) gene by IL-11 suggested that a MAP kinase phosphatase may be involved in IL-11-mediated signal transduction. Our data also suggested that tyrosine phosphorylation of Stat91 and related transcriptional factors is involved in IL-11 signaling but is not sufficient for the activation of primary response genes such as JunB, tis11, tis8 and MAP kinase phosphatase in mouse preadipocytes. The understanding of signal transduction pathways mediated by IL-11 and related cytokines may help to define the common and unique biological properties of these growth factors.
白细胞介素-11（IL-11）是一种多功能细胞因子，与白细胞介素-6（IL-6）、白血病抑制因子（LIF）、抑瘤素M（OSM）和睫状神经营养因子（CNTF）在生物学上相关。已表明这些细胞因子可利用共同的信号转导子gp130。我们已证明，Jak酪氨酸激酶、丝裂原活化蛋白激酶（MAP激酶）和pp90rsk可被IL-11及相关细胞因子高度激活。此外，我们已确定pp90rsk是对IL-11诱导的初级反应基因表达至关重要的H7敏感蛋白激酶之一。此外，IL-11对3CH134（一种MAP激酶磷酸酶）基因的激活表明，一种MAP激酶磷酸酶可能参与IL-11介导的信号转导。我们的数据还表明，Stat91及相关转录因子的酪氨酸磷酸化参与IL-11信号传导，但不足以激活小鼠前脂肪细胞中的初级反应基因，如JunB、tis11、tis8和MAP激酶磷酸酶。对IL-11及相关细胞因子介导的信号转导途径的理解可能有助于明确这些生长因子的共同和独特生物学特性。
