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Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway.

作者信息

Nakajima K, Matsuda T, Fujitani Y, Kojima H, Yamanaka Y, Nakae K, Takeda T, Hirano T

机构信息

Division of Molecular Oncology, Osaka University Medical School, Japan.

出版信息

Ann N Y Acad Sci. 1995 Jul 21;762:55-70. doi: 10.1111/j.1749-6632.1995.tb32314.x.

DOI:10.1111/j.1749-6632.1995.tb32314.x
PMID:7545378
Abstract
摘要

相似文献

1
Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway.
Ann N Y Acad Sci. 1995 Jul 21;762:55-70. doi: 10.1111/j.1749-6632.1995.tb32314.x.
2
Interleukin (IL)-11--mediated signal transduction.白细胞介素(IL)-11介导的信号转导。
Ann N Y Acad Sci. 1995 Jul 21;762:31-40; discussion 40-1. doi: 10.1111/j.1749-6632.1995.tb32312.x.
3
Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction.
FEBS Lett. 1995 Feb 27;360(2):137-43. doi: 10.1016/0014-5793(95)00076-l.
4
Membrane-bound and soluble interleukin-6 receptor: studies on structure, regulation of expression, and signal transduction.
Ann N Y Acad Sci. 1995 Jul 21;762:222-36; discussion 236-7. doi: 10.1111/j.1749-6632.1995.tb32328.x.
5
Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.Shc通过与gp130和Jak2激酶相互作用介导白细胞介素-6信号传导。
J Immunol. 1997 May 1;158(9):4097-103.
6
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.通过白细胞介素-6信号转导受体蛋白gp130激活蛋白酪氨酸磷酸酶SHP2需要酪氨酸激酶Jak1,并限制急性期蛋白的表达。
Biochem J. 1998 Nov 1;335 ( Pt 3)(Pt 3):557-65. doi: 10.1042/bj3350557.
7
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.细胞因子利用gp130及相关转导分子激活STAT3涉及一种需要H7敏感激酶的二级修饰。
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6915-9. doi: 10.1073/pnas.92.15.6915.
8
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.白血病抑制因子受体和制瘤素M受体在与糖蛋白130形成的异二聚体复合物中对信号转导的作用。
J Immunol. 1999 Dec 15;163(12):6651-8.
9
Structure and function of a new STAT-induced STAT inhibitor.一种新型STAT诱导的STAT抑制剂的结构与功能
Nature. 1997 Jun 26;387(6636):924-9. doi: 10.1038/43219.
10
Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association.白细胞介素-6家族细胞因子信号转导分子gp130对Fes酪氨酸激酶的激活及其关联。
J Biol Chem. 1995 May 12;270(19):11037-9. doi: 10.1074/jbc.270.19.11037.

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Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor.蛋白质组学鉴定癌蛋白信号转导和转录激活因子3(STAT3)为新型Skp1抑制剂的作用靶点。
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Pathological role of IL-6 in the experimental allergic bronchial asthma in mice.白细胞介素-6在小鼠实验性变应性支气管哮喘中的病理作用
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Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation.白细胞介素6诱导NFATc2表达促进2型辅助性T细胞分化。
J Exp Med. 2002 Jul 1;196(1):39-49. doi: 10.1084/jem.20020026.
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Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1.Stat1的细胞外信号依赖性核输入是由与NPI-1而非Rch1形成核孔靶向复合物介导的。
EMBO J. 1997 Dec 1;16(23):7067-77. doi: 10.1093/emboj/16.23.7067.
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Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6.白细胞介素-6刺激的PC12细胞中STAT3和丝裂原活化蛋白激酶对神经突生长的双重调控
EMBO J. 1997 Sep 1;16(17):5345-52. doi: 10.1093/emboj/16.17.5345.
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IL-6 cytokine family and signal transduction: a model of the cytokine system.白细胞介素-6细胞因子家族与信号转导:细胞因子系统模型
J Mol Med (Berl). 1996 Jan;74(1):1-12. doi: 10.1007/BF00202068.
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A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.Stat3在白细胞介素-6诱导的M1白血病细胞生长和分化调控中起核心作用。
EMBO J. 1996 Jul 15;15(14):3651-8.
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Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.分化和生长抑制信号通过gp130的胞质区域产生,该区域对Stat3激活至关重要。
EMBO J. 1996 Apr 1;15(7):1557-65.