Celiński K, Kleinrok Z, Pokora J, Czechowska G, Skrzydło-Radomańska B, Cichoz-Lach H
Department of Gastroenterology, University School of Medicine, Lublin, Poland.
J Physiol Pharmacol. 1995 Jun;46(2):163-7.
The effects of caerulein-induced acute pancreatitis (AP) on the levels of 5-HT and 5-HIAA in pancreas, liver, brain, kidney and different parts of the digestive tract in rats have been studied. The acute pancreatitis was induced by the continuous intravenous infusion of caerulein in the doses of 5 x 10(-6) g/kg/h and 7.5 x 10(-6) g/kg/h for 12 hours, and the 5-HT and 5-HIAA concentrations were determined by the method of Curzon and Green. The changes evoked by caerulein varied qualitatively and quantitatively between organs. The significant decrease of both 5-HT and 5-HIAA was observed in pancreas, liver, brain and kidney while in the stomach there was a significant fall of 5-HT level accompanied by the relevant increase of 5-HIAA level. In the duodenum, an opposite effect was noticed, the level of 5-HT was higher than normal whereas the 5-HIAA level was reduced. The significant decrease of the 5-HT and 5-HIAA levels in pancreas observed in the present study suggests the importance of 5-HT in the development of acute pancreatitis.
研究了蛙皮素诱导的大鼠急性胰腺炎（AP）对胰腺、肝脏、脑、肾及消化道不同部位5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）水平的影响。通过以5×10⁻⁶ g/kg/h和7.5×10⁻⁶ g/kg/h的剂量持续静脉输注蛙皮素12小时诱导急性胰腺炎，采用Curzon和Green的方法测定5-HT和5-HIAA浓度。蛙皮素引起的变化在不同器官之间存在质和量的差异。在胰腺、肝脏、脑和肾中观察到5-HT和5-HIAA均显著降低，而在胃中5-HT水平显著下降，同时5-HIAA水平相应升高。在十二指肠中观察到相反的效应，5-HT水平高于正常，而5-HIAA水平降低。本研究中观察到胰腺中5-HT和5-HIAA水平显著降低，提示5-HT在急性胰腺炎发生发展中的重要性。
