Matsuo S, Okamoto K
Department of Clinical Haematology, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
Life Sci. 1995;57(13):PL165-9. doi: 10.1016/0024-3205(95)02080-3.
Influence of FK-506 and ganglioside (GM3) on acquired immunity to Hymenolepis nana reinfection was examined in BALB/c mice. Treatment of mice with FK-506 abolished the acquired immunity to challenge infection with eggs of H. nana when the agent was injected inraperitoneally at daily doses of 9.0 to 11.0 mg/kg (but not 8.5 mg/kg) on days -1, 0, 1, 2, and 3 relative to the challenge. Intravenous injection of GM3 at a daily dose of 10.0 mg/kg could not produce an immunosuppressive effect on the acquired immunity. Combination treatment with 8.5 mg/kg/day FK-506 and 10.0 mg/kg/day of GM3 inhibited the acquired immunity. These results suggest that GM3 will be a good candidate for a clinical supplementary immunosuppressive agent.
在BALB/c小鼠中检测了FK-506和神经节苷脂（GM3）对微小膜壳绦虫再感染获得性免疫的影响。当在相对于攻击感染的第-1、0、1、2和3天以每日剂量9.0至11.0mg/kg（但不是8.5mg/kg）腹腔注射FK-506时，用其治疗小鼠可消除对微小膜壳绦虫卵攻击感染的获得性免疫。每日剂量10.0mg/kg静脉注射GM3对获得性免疫不会产生免疫抑制作用。8.5mg/kg/天的FK-506与10.0mg/kg/天的GM3联合治疗可抑制获得性免疫。这些结果表明，GM3将是临床辅助免疫抑制剂的良好候选药物。
