Kietzmann M
Institut für Pharmakologie, Pharmazie und Toxikologie, Veterinärmedizinischen Fakultät der Universität Leipzig.
Tierarztl Prax. 1995 Jun;23(3):218-23.
Pruritus is a predominant and serious phenomenon of various skin diseases. As mediators of pruritus, histamine, serotonin (hydroxytryptamine), eicosanoids, neuropeptides, cytokines and proteases are known. The symptomatic treatment of pruritus is variable. Glucocorticoids are well known antipruritic drugs. H1-antihistaminics are used frequently. But the efficacy of these drugs is questionable in dogs. Additionally, mast cell stabilisators, unsaturated fatty acids (i. e. primrose oil, fish oil) and other antipruritic agents (local anesthetics) are used.
瘙痒是各种皮肤疾病中主要且严重的现象。作为瘙痒的介质，已知有组胺、5-羟色胺（血清素）、类花生酸、神经肽、细胞因子和蛋白酶。瘙痒的对症治疗方法多样。糖皮质激素是众所周知的止痒药物。H1抗组胺药也经常使用。但这些药物对犬类的疗效存疑。此外，还会使用肥大细胞稳定剂、不饱和脂肪酸（如月见草油、鱼油）及其他止痒剂（局部麻醉剂）。
