马德里地区人类免疫缺陷病毒1型的分子流行病学

Molecular epidemiology of HIV-1 in Madrid.

作者信息

Rojas J M, Dopazo J, Nájera I, Sánchez-Palomino S, Olivares I, Martin M J, Bernal A, García Saiz A, Nájera R, López-Galíndez C

机构信息

Centro de Biología Celular y Retrovirus, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

出版信息

Virus Res. 1994 Mar;31(3):331-42. doi: 10.1016/0168-1702(94)90026-4.

DOI:10.1016/0168-1702(94)90026-4

PMID:7545926

Abstract

Thirteen HIV-1 isolates from patients of different risk groups in Madrid (Spain) have been analyzed at the genetic level. Two distinct lineages of subtype B have been detected among the HIV-1 circulating in this area: one was related to SF-2/RF strains, whereas the other consists of a more heterogeneous group related to reference strain III-B. Variants of each lineage appeared to circulate preferentially within a risk group: III-B among intravenous drug users, and RF/SF-2 among male homosexuals.

摘要

对来自西班牙马德里不同风险群体患者的13株HIV-1分离株进行了基因水平分析。在该地区流行的HIV-1中检测到两种不同的B亚型谱系：一种与SF-2/RF毒株相关，而另一种由与参考毒株III-B相关的更具异质性的群体组成。每个谱系的变体似乎在一个风险群体中优先传播：静脉吸毒者中的III-B，以及男同性恋者中的RF/SF-2。