卡马西平的长期治疗会增强乙醇对小鼠的刺激作用。
Prolonged treatment with carbamazepine increases the stimulatory effects of ethanol in mice.
作者信息
Camarini R, Andreatini R, Monteiro M G
机构信息
Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.
出版信息
Alcohol. 1995 Jul-Aug;12(4):305-8. doi: 10.1016/0741-8329(95)00002-9.
Carbamazepine (CBZ) has been used in the treatment of alcohol withdrawal (AW). However, cases of induction of euphoric feelings when mixed with alcohol have been reported. We verified whether CBZ could potentiate ethanol stimulatory effects in animals. Two groups of mice were injected with saline (group I) or 2 g/kg ethanol (group II) IP, for 20 days. On the next day, each group was divided into two subgroups that received either a single dose of CBZ (10 mg/kg) or vehicle IP, followed, 30 min later, by saline or ethanol injection. Locomotor activity was measured. Acute CBZ did not change locomotor activity of ethanol-treated mice. Treatment with CBZ or vehicle continued for 6 days. Finally, on the 28th day, 30 min after the last CBZ or vehicle injection, an ethanol challenge was given to group II and a saline injection to group I. The results showed a significant potentiation of ethanol stimulatory effects by chronic CBZ treatment. Data indicated that CBZ should be cautiously administered to alcohol-dependent patients.
卡马西平（CBZ）已被用于治疗酒精戒断（AW）。然而，有报告称其与酒精混合使用时会引发欣快感。我们验证了CBZ是否会增强动物对乙醇的刺激作用。将两组小鼠腹腔注射生理盐水（I组）或2 g/kg乙醇（II组），持续20天。次日，每组再分为两个亚组，分别腹腔注射单剂量的CBZ（10 mg/kg）或赋形剂，30分钟后，再分别注射生理盐水或乙醇。测量运动活性。急性给予CBZ并未改变乙醇处理小鼠的运动活性。CBZ或赋形剂处理持续6天。最后，在第28天，在最后一次注射CBZ或赋形剂30分钟后，II组给予乙醇激发试验，I组给予生理盐水注射。结果显示，慢性CBZ处理可显著增强乙醇的刺激作用。数据表明，对于酒精依赖患者，应谨慎使用CBZ。
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