Dyr W, Kostowski W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Sobieskiego, Poland.
Alcohol. 1995 Jul-Aug;12(4):387-91. doi: 10.1016/0741-8329(95)00023-k.
Two 5-HT3 receptor antagonists, tropisetron (1 and 10 ng) and ondansetron (10 and 100 ng) were tested for effects on ethanol drinking in Wistar male rats after bilateral microinjection into the amygdala. The animals had limited access (2 h/day) to the 10% (v/v) ethanol solution, food and water were available ad lib during the scheduled access period. Both drugs caused a decrease in ethanol drinking. Tropisetron (1 and 10 ng) decreased ethanol intake during the first hour of access. The lower dose (10 ng) of ondansetron was more effective than the higher (100 ng) dose. The finding implicates amygdaloid 5-HT3 receptors in the mechanism of ethanol intake in Wistar rats.
将两种5-羟色胺3（5-HT3）受体拮抗剂托烷司琼（1纳克和10纳克）和昂丹司琼（10纳克和100纳克）双侧微量注射到Wistar雄性大鼠杏仁核后，检测它们对大鼠乙醇摄取量的影响。动物对10%（v/v）乙醇溶液的摄取时间有限（每天2小时），在规定的摄取期间可自由获取食物和水。两种药物均使乙醇摄取量减少。托烷司琼（1纳克和10纳克）在摄取的第一小时使乙醇摄入量减少。较低剂量（10纳克）的昂丹司琼比较高剂量（100纳克）更有效。这一发现表明杏仁核5-HT3受体参与了Wistar大鼠乙醇摄取的机制。
