Elia M, Musumeci S A, Ferri R, Bergonzi P
Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
Am J Ment Retard. 1995 Jul;100(1):6-16.
Clinical and neurophysiological findings for 28 patients with mental retardation, autism, and epilepsy were described. Correct classification of seizure type and epileptic syndrome (when possible), etiology, severity of autism and epilepsy, EEG findings, and neuroimaging findings were given. No particular epileptic syndrome was found to be more frequently correlated to autism, severity of autism was not correlated with a more pronounced tendency to develop seizures, and females with autism were more frequently affected by seizures than were males. In conclusion, the risk for epilepsy does not seem to be correlated to autism itself, but the same noxious event induces autism and epilepsy. The severity of epilepsy is strictly correlated with its etiopathogenetic mechanisms.
描述了28例智力发育迟缓、自闭症和癫痫患者的临床及神经生理学发现。给出了癫痫发作类型和癫痫综合征（如可能）的正确分类、病因、自闭症和癫痫的严重程度、脑电图结果及神经影像学结果。未发现特定的癫痫综合征与自闭症更常相关，自闭症的严重程度与癫痫发作的更明显倾向无关，自闭症女性比男性更易受癫痫发作影响。总之，癫痫风险似乎与自闭症本身无关，而是同一有害事件诱发了自闭症和癫痫。癫痫的严重程度与其病因发病机制密切相关。
