Nakao Y, Sakihama N, Kumagami H
Department of Otolaryngology, Nagasaki University, School of Medicine, Japan.
Eur Arch Otorhinolaryngol. 1995;252(4):255-7. doi: 10.1007/BF00179921.
Changes in vascular permeability to sodium fluorescein following experimentally induced nerve lesions were examined in the rabbit facial nerve. Sodium fluorescein was injected intravenously as a permeability tracer and then localized by fluorescence microscopy. In control nerves, endoneurium showed only slight fluorescence while intense fluorescence was observed in the epineurium and perineurium. In nerves demonstrating edema and Wallerian degeneration, endoneurium was found to have an increased accumulation of tracer. This increased endoneurial vascular permeability in facial nerve lesions may explain nerve enhancement seen in gadolinium-enhanced magnetic resonance imaging in patients with facial nerve paralysis.
在兔面神经中研究了实验性诱导神经损伤后血管对荧光素钠通透性的变化。静脉注射荧光素钠作为通透性示踪剂，然后通过荧光显微镜进行定位。在对照神经中，神经内膜仅显示轻微荧光，而在神经外膜和神经束膜中观察到强烈荧光。在出现水肿和华勒氏变性的神经中，发现神经内膜示踪剂蓄积增加。面神经损伤时神经内膜血管通透性的增加可能解释了面神经麻痹患者钆增强磁共振成像中所见的神经强化。
