Dittrich H C, Bales G L, Kuvelas T, Hunt R M, McFerran B A, Greener Y
University of California, San Diego, USA.
J Am Soc Echocardiogr. 1995 Jul-Aug;8(4):465-74. doi: 10.1016/s0894-7317(05)80333-5.
A new intravenously administered ultrasound contrast agent was studied in eight dogs during intermittent coronary artery occlusion. The area of the myocardial contrast defect was compared with that of the acute wall motion abnormality induced by coronary occlusion. A close correlation was found between these two independent measures of acute myocardial ischemia. The peak change in myocardial intensity during coronary occlusion was significantly less than for the same segment before ischemia and for a remote nonischemic segment. This new, intravenously administered ultrasound contrast agent can be used to evaluate the spatial distribution of hypoperfused myocardium and should therefore prove valuable in the clinical evaluation of ischemic syndromes.
在八只犬间歇性冠状动脉闭塞期间，对一种新的静脉注射超声造影剂进行了研究。将心肌对比缺损区域与冠状动脉闭塞诱发的急性室壁运动异常区域进行了比较。发现这两种急性心肌缺血的独立测量方法之间存在密切相关性。冠状动脉闭塞期间心肌强度的峰值变化明显小于缺血前同一节段以及远处非缺血节段。这种新的静脉注射超声造影剂可用于评估灌注不足心肌的空间分布，因此在缺血综合征的临床评估中应具有重要价值。
