Ishida S, Takahashi N, Nakagawa M, Fujino T, Saikawa T, Ito M
Department of Laboratory Medicine, Oita Medical University, Japan.
Br Heart J. 1995 Aug;74(2):159-62. doi: 10.1136/hrt.74.2.159.
To investigate the relation between QT and RR intervals in the sick sinus syndrome or high degree atrioventricular block.
32 patients with episodes of prolonged RR intervals (> or = 2.6 s) on Holter electrocardiographic recordings.
QT and RR intervals were measured manually every 100 to 150 beats on electrocardiographic strips reprinted from the Holter tape over 24 hours. The slope of the QT/RR relation was determined by the linear regression equation for RR intervals < or = 1.4 s (slope 1) and > 1.4 s (slope 2).
Slope 2 (0.0068 (0.0030)) was significantly lower than slope 1 (0.0824 (0.0059), P < 0.0001) in the overall patient population. Slopes 1 and 2 were significantly lower (P < 0.001) in the 23 patients with QT intervals at the preceding RR interval of 1 s (QT1s) of < 0.44 s (0.0692 (0.0053) and 0.0019 (0.0030), respectively) than in the nine patients with QT1s intervals > or = 0.44 s (0.1159 (0.0091) and 0.0194 (0.0055), respectively). Slopes 1 and 2 correlated positively with QT1s interval in all patients.
The QT/RR relation was comparatively flat when the RR interval was prolonged. Patients with prolonged QT intervals showed exaggerated prolongation of the QT interval with prolonged cycle lengths when compared with patients with normal QT intervals.
研究病态窦房结综合征或高度房室传导阻滞患者QT间期与RR间期的关系。
32例动态心电图记录显示RR间期延长（≥2.6秒）发作的患者。
在从24小时动态心电图磁带重印的心电图条带上，每100至150个心搏手动测量QT间期和RR间期。QT/RR关系的斜率由RR间期≤1.4秒（斜率1）和>1.4秒（斜率2）的线性回归方程确定。
总体患者人群中，斜率2（0.0068（0.0030））显著低于斜率1（0.0824（0.0059），P<0.0001）。在23例前一个RR间期为1秒时QT间期（QT1s）<0.44秒的患者中，斜率1和斜率2显著更低（P<0.001）（分别为0.0692（0.0053）和0.0019（0.0030）），而在9例QT1s间期≥0.44秒的患者中（分别为0.1159（0.0091）和0.0194（0.0055））。在所有患者中，斜率1和斜率2与QT1s间期呈正相关。
当RR间期延长时，QT/RR关系相对平坦。与QT间期正常的患者相比，QT间期延长的患者在心动周期长度延长时QT间期延长更为明显。
