Goldenberg D L
Newton-Wellesley Hospital, Massachusetts, USA.
Curr Opin Rheumatol. 1995 Jul;7(4):310-4. doi: 10.1097/00002281-199507000-00008.
A number of experimental models of bacterial arthritis demonstrated that immune factors, especially directed cytokines, play an important role in cartilage destruction. The most important studies in bacterial arthritis were a review of the clinical manifestations of gonococcal arthritis and two reports of the use of polymerase chain reaction to detect Neisseria gonorrhoeae DNA in synovial fluid. Polymerase chain reaction may be an important diagnostic test in culture-negative cases and may be very helpful in understanding the pathophysiology of gonococcal arthritis.
多种细菌性关节炎的实验模型表明，免疫因子，尤其是趋化因子，在软骨破坏中起重要作用。关于细菌性关节炎的最重要研究包括一篇关于淋菌性关节炎临床表现的综述，以及两篇关于使用聚合酶链反应检测滑液中淋病奈瑟菌DNA的报告。聚合酶链反应可能是培养阴性病例的一项重要诊断试验，并且可能对理解淋菌性关节炎的病理生理学非常有帮助。
