Meier J L, Beekmann S E
University of Iowa, Iowa City, USA.
Curr Opin Rheumatol. 1995 Jul;7(4):329-36. doi: 10.1097/00002281-199507000-00011.
The number of cases of tuberculous bone or joint infection reported annually in the United States has been rising, but it decreased slightly in 1993. Management of skeletal tuberculosis is a complex and evolving issue that requires knowledge of the treatment of drug-resistant organisms. Nontuberculous mycobacteria also may cause skeletal infections, which are often located in tenosynovium or osteoarticular components of the hand or wrist but may occur at other skeletal sites, particularly when there is underlying immunosuppression. Identification of the organism and determination of its drug sensitivities are crucial for providing optimal therapy. Fungal infections of bone or joint can be difficult to treat, but the availability of fluconazole and itraconazole has extended our therapeutic options for some mycoses.
美国每年报告的结核性骨或关节感染病例数一直在上升，但在1993年略有下降。骨骼结核病的管理是一个复杂且不断发展的问题，需要了解耐药菌的治疗方法。非结核分枝杆菌也可能引起骨骼感染，这些感染通常位于手部或腕部的腱鞘或骨关节部位，但也可能发生在其他骨骼部位，尤其是在存在潜在免疫抑制的情况下。识别病原体并确定其药物敏感性对于提供最佳治疗至关重要。骨或关节的真菌感染可能难以治疗，但氟康唑和伊曲康唑的出现为我们治疗某些真菌病提供了更多的治疗选择。
