Nikolopoulou V, Katsakoulis E, Thomopoulos K, Tsiotos P
Department of Internal Medicine, University Hospital, Patras, Greece.
Br J Clin Pract. 1995 Jul-Aug;49(4):186-8.
A study was conducted of 816 patients with peptic ulcer haemorrhage, comparing outcome before and after the introduction of endoscopic therapy. The control group comprised 505 patients admitted with bleeding due to benign peptic ulcer over a 5-year period before endoscopic therapy, and 311 patients after introduction of endoscopic therapy were studied prospectively. The two groups were well matched for age, sex, shock, endoscopic findings and use of ulcerogenic drugs. The introduction of endoscopic therapy was associated with a reduction in surgical intervention and mortality rates for gastric and duodenal ulcer. The beneficial effects of endoscopic therapy appear to be due to a reduction in the need for surgical intervention in patients with an ulcer base visible vessel. The authors suggest that endoscopic injection therapy may result in an improved outcome from peptic ulcer haemorrhage. Adrenaline injection treatment seems to be the treatment of choice in view of its simplicity, low cost and availability.
对816例消化性溃疡出血患者进行了一项研究，比较了内镜治疗前后的结果。对照组包括505例在内镜治疗前5年期间因良性消化性溃疡出血入院的患者，对311例引入内镜治疗后的患者进行了前瞻性研究。两组在年龄、性别、休克、内镜检查结果和使用致溃疡药物方面匹配良好。内镜治疗的引入与胃和十二指肠溃疡的手术干预和死亡率降低有关。内镜治疗的有益效果似乎是由于减少了溃疡底部可见血管患者的手术干预需求。作者认为内镜注射治疗可能会改善消化性溃疡出血的预后。鉴于肾上腺素注射治疗简单、成本低且易于获得，似乎是首选治疗方法。
