妊娠期生长受限：利用电诱导热胎盘损伤建立的兔实验模型
Growth retardation in pregnancy: experimental model in the rabbit employing electrically induced thermal placental injury.
作者信息
Rosati P, Exacoustos C, Puggioni G F, Mancuso S
机构信息
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Int J Exp Pathol. 1995 Jun;76(3):179-81.
Intrauterine growth retardation involves haemodynamic modifications in the uterus and placenta. In order to study intrauterine growth retardation we obtained an electrically induced thermal placental injury in a rabbit experimental model. The effects on weight of fetuses, placentas and single organs were recorded and statistically analysed. Fetal growth retardation was recorded in 71% of fetuses exposed to 15 mA direct current per 40 seconds, and resulted in only 7.9% of normal fetuses. The data presented in this study have shown a retardation of fetal growth particularly evident in the liver weight with a relative sparing of brain development. Kidney and heart do not present a statistically significant reduction in growth. This growth retardation model is simple and readily reproducible.
宫内生长迟缓涉及子宫和胎盘的血流动力学改变。为了研究宫内生长迟缓，我们在兔实验模型中造成了电诱导的胎盘热损伤。记录并统计分析了对胎儿、胎盘和单个器官重量的影响。在每40秒暴露于15毫安直流电的胎儿中，71%出现了胎儿生长迟缓，而正常胎儿仅占7.9%。本研究呈现的数据表明，胎儿生长迟缓在肝脏重量方面尤为明显，而脑发育相对未受影响。肾脏和心脏的生长没有统计学上的显著降低。这种生长迟缓模型简单且易于重复。
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