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鞘内持续注射巴氯芬与选择性功能性后根切断术治疗脑瘫相关痉挛性四肢瘫的成本分析

Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy.

作者信息

Steinbok P, Daneshvar H, Evans D, Kestle J R

机构信息

Division of Neurosurgery, British Columbia's Children's Hospital, Vancouver, Canada.

出版信息

Pediatr Neurosurg. 1995;22(5):255-64; discussion 265. doi: 10.1159/000120911.

DOI:10.1159/000120911
PMID:7547458
Abstract

The purpose of the study was to analyze the relative cost of selective functional posterior rhizotomy (SFPR) and continuous intrathecal baclofen in the treatment of children with severe spastic quadriplegia related to cerebral palsy. No attempt was made to analyze the efficacy of the two types of treatment. Nine children with spastic quadriplegia secondary to cerebral palsy in whom continuous intrathecal baclofen was attempted were matched as closely as possible with a group of 10 patients with spastic quadriplegia out of a total of 100 children who had undergone SFPR in the same time period. Clinical care flow charts were created to identify the various points of contact with members of the health care team, so that cost points could be identified and costs calculated. The cost per patient up to 1 year a after treatment CDN$ 64,163.10 for patients with implanted pumps for continuous intrathecal baclofen versus CDN$ 16,913.54 for SFPR. When adjustments were made to exclude costs and savings associated with research protocols, the average for the baclofen group decreased to approximately CDN$ 63,000, with minimal change for the SFPR group. The higher cost per patient on baclofen was related to the cost associated with screening patients who did not go on to have implantation of a continuous infusion pump, and to additional hospitalization for complications in the baclofen group. It is cautioned that this cost analysis was based on the experience at British Columbia's Children's Hospital, and the results may not be generalizable to other institutions or to other patient populations.

摘要

本研究的目的是分析选择性功能性后根切断术(SFPR)和鞘内持续注射巴氯芬治疗与脑瘫相关的严重痉挛性四肢瘫患儿的相对成本。未尝试分析这两种治疗方法的疗效。对9例尝试鞘内持续注射巴氯芬的脑瘫继发痉挛性四肢瘫患儿,与同期100例接受SFPR治疗的患儿中的10例痉挛性四肢瘫患儿尽可能紧密地进行匹配。创建临床护理流程图以确定与医疗团队成员的各个接触点,以便确定成本点并计算成本。治疗后1年内,鞘内持续注射巴氯芬并植入泵的患者人均成本为64,163.10加元,而接受SFPR治疗的患者人均成本为16,913.5加元。当进行调整以排除与研究方案相关的成本和节省时,巴氯芬组的平均值降至约63,000加元,而SFPR组变化极小。巴氯芬治疗的患者人均成本较高与筛查未继续植入持续输注泵的患者的成本以及巴氯芬组并发症的额外住院费用有关。需要注意的是,该成本分析基于不列颠哥伦比亚省儿童医院的经验,结果可能不适用于其他机构或其他患者群体。

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