Esquivel C O, Martinez O, Krams S, Lim J, So S K, Concepcion W, Cox K L, Keeffe E B
Department of Transplantation, California Pacific Medical Center, San Francisco, USA.
Clin Transpl. 1994:163-71.
A number of modifications in patient selection, operative technique, and immunosuppressive management have greatly contributed to the success of the liver transplant program at CPMC. Graft rejection and the timely detection of EBV infection are ongoing problems in hepatic transplantation that are foci of active research in our field. To address these issues, our group is investigating the activity of cytokines and adhesion molecules using sophisticated molecular techniques, and we are developing a sensitive assay for EBV markers in blood. These and other projects currently in progress will continue when we move our liver transplant program to Stanford University Medical Center in January 1995.
在患者选择、手术技术和免疫抑制管理方面的一些改进，对加州太平洋医疗中心肝脏移植项目的成功起到了极大的推动作用。移植物排斥反应以及EB病毒感染的及时检测，是肝移植中持续存在的问题，也是我们这个领域积极研究的重点。为了解决这些问题，我们团队正在使用先进的分子技术研究细胞因子和黏附分子的活性，并且正在开发一种针对血液中EB病毒标志物的灵敏检测方法。当我们在1995年1月将肝脏移植项目转移到斯坦福大学医学中心时，这些以及其他正在进行的项目将会继续开展。
