In de Braekt M M, Maltha J C, Kuijpers-Jagtman A M
Department of Orthodontics and Oral Histology, University of Nijmegen, The Netherlands.
Cleft Palate Craniofac J. 1995 Jul;32(4):290-8. doi: 10.1597/1545-1569_1995_032_0290_pllami_2.3.co_2.
This article reports on the histologic findings from a larger study that was designed to investigate whether the attachment of scar tissue to underlying bone, which is normally found after palatal surgery, can be prevented by using biodegradable poly-(L-lactic) acid membranes. Von Langenbeck's procedure was simulated in 12-week-old beagle dogs without clefts. In one group normal wound healing was allowed. In two groups, membranes were inserted immediately after surgery or 3 weeks thereafter. Sham and control groups were also included. Histologic evaluation was carried out at regular intervals. Reports have been published on other aspects, such as clinical wound healing, contraction and maxillary arch development in beagle dogs following this treatment. After direct implantation of membranes, wound healing was retarded. Disintegration of the membranes started soon after implantation and remaining particles were surrounded by a fibroblastic sheath and a fibrous capsule. At sites where membrane particles persisted, attachment of the scar tissue to the underlying bone by Sharpey's fibers was prevented.
本文报道了一项规模更大的研究的组织学研究结果，该研究旨在调查腭裂手术后通常会出现的瘢痕组织与下方骨骼的附着是否可以通过使用可生物降解的聚（L-乳酸）酸膜来预防。在12周龄的非腭裂比格犬身上模拟了冯·朗根贝克手术。一组允许正常伤口愈合。在另外两组中，在手术后立即或3周后插入膜。还包括假手术组和对照组。定期进行组织学评估。关于这种治疗后比格犬的其他方面，如临床伤口愈合、收缩和上颌弓发育，已有报道发表。直接植入膜后，伤口愈合延迟。膜植入后不久就开始解体，残留颗粒被成纤维细胞鞘和纤维囊包围。在膜颗粒持续存在的部位，夏皮氏纤维将瘢痕组织与下方骨骼的附着得以预防。
