[与HIV感染相关的中枢神经系统疾病中的α肿瘤坏死因子]

[Alpha tumor necrosis factor in central nervous system disease associated with HIV infection].

作者信息

Calvo Manuel E, Arranz Garcia F, Sánchez-Portocarrero J, Roca Arbones V, Puente M, Elias Arcalis A, Pérez-Cecilia E, Nieto Sánchez A, Espinos Pérez D

机构信息

Servicio de Medicina Interna I, Hospital Universitario San Carlos, Facultad de Medicina, Universidad Complutense, Madrid.

出版信息

An Med Interna. 1995 Jun;12(6):263-6.

PMID:7548640

Abstract

The aim of the present study is to evaluate the relationship between the alpha tumor necrosis factor (TNF-alpha), interleukin 1 beta (IL-1 beta) and the neurological disease associated to the HIV-1 infection and different neurological manifestations (15 infections of the CNS and 11 AIDS-dementia complexes) and 14 from a control group. The mean value of TNF-alpha in CSF of patients with HIV-1 infection and AIDS-dementia complex was 19.8 +/- 30.6 pg/ml, superior to that of the control group (p < 0.05). The group of patients with HIV-1 and opportunistic CNS infection has a TNF-alpha value of 28.5 +/- 37.8 pg/ml, that is superior to that of the patients with the AIDS-dementia complex (TNF-alpha = 7.9 +/- 9.4 pg ml; p < 0.05). Within the group of patients with a CNS infection, the value of TNF-alpha was greater in those in the acute phase (44.2 +/- 42.4 pg/ml) than in those in the chronic phase (6.8 +/- 7.6 pg/ml; p < 0.05). The TNF-alpha in the CSF is a good marker of infection of the CNS in the HIV-1 infection.

摘要

本研究的目的是评估α肿瘤坏死因子（TNF-α）、白细胞介素1β（IL-1β）与HIV-1感染相关的神经系统疾病以及不同神经表现（15例中枢神经系统感染和11例艾滋病痴呆综合征）之间的关系，并与14例对照组进行比较。HIV-1感染和艾滋病痴呆综合征患者脑脊液中TNF-α的平均值为19.8±30.6 pg/ml，高于对照组（p<0.05）。HIV-1和机会性中枢神经系统感染患者组的TNF-α值为28.5±37.8 pg/ml，高于艾滋病痴呆综合征患者组（TNF-α=7.9±9.4 pg/ml；p<0.05）。在中枢神经系统感染患者组中，急性期患者的TNF-α值（44.2±42.4 pg/ml）高于慢性期患者（6.8±7.6 pg/ml；p<0.05）。脑脊液中的TNF-α是HIV-1感染中枢神经系统感染的良好标志物。