Lemdani M, Pons O
Biométrie, Institut National de la Recherche Agronomique, Jouy-en- Josas, France.
Biometrics. 1995 Sep;51(3):1033-41.
This report concerns likelihood ratio tests in a heterogeneous model for linkage, where the recombination fraction has a binomial mixture distribution with an unknown proportion of unlinked families. We consider families of unequal sizes with known or unknown phase data. In both cases, the limit distributions of the linkage test statistics are a mixture of a mass at ) and of a X2/1 distribution in equal proportions and homogeneity test statistics tend to the supremum of Gaussian processes. The critical values of the homogeneity tests are simulated, and the power functions of the linkage and homogeneity tests are compared in a simulation study.
本报告涉及连锁分析的异质性模型中的似然比检验，其中重组率具有二项混合分布，未连锁家系的比例未知。我们考虑大小不等且相位数据已知或未知的家系。在这两种情况下，连锁检验统计量的极限分布是在0处的一个质量点和一个自由度为1的卡方分布按等比例混合而成，并且同质性检验统计量趋于高斯过程的上确界。对同质性检验的临界值进行了模拟，并在一项模拟研究中比较了连锁检验和同质性检验的功效函数。
