Abbas Z, Hussainy A S, Ibrahim F, Jafri S M, Shaikh H, Khan A H
Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
J Gastroenterol Hepatol. 1995 May-Jun;10(3):331-3. doi: 10.1111/j.1440-1746.1995.tb01102.x.
In order to demonstrate the presence of Helicobacter pylori in the metaplastic epithelium of Barrett's oesophagus and to evaluate its possible association with this entity, we examined 29 cases of Barrett's oesophagus where concomitant antral biopsies were also available. These cases were compared with an equal number of age and sex matched controls of uncomplicated reflux oesophagitis. H. pylori was present in 11 of 29 cases of Barrett's oesophagus (38%). No increase in the frequency of H. pylori antral gastritis was found in patients of Barrett's oesophagus compared to the control group of uncomplicated reflux oesophagitis. The positivity of Barrett's oesophagus for H. pylori correlated with the presence of H. pylori antral gastritis (P < 0.05), although in two cases of H. pylori-positive Barrett's oesophagus antral biopsies were negative for H. pylori. No difference was found in the severity of inflammatory and dysplastic changes of H. pylori-positive and H. pylori-negative Barrett's oesophagus. Presence of H. pylori does not seem to alter the natural history of Barrett's oesophagus.
为了证明巴雷特食管化生上皮中幽门螺杆菌的存在，并评估其与该病变的可能关联，我们检查了29例巴雷特食管病例，这些病例同时也有胃窦活检样本。将这些病例与同等数量的年龄和性别匹配的单纯反流性食管炎对照组进行比较。29例巴雷特食管病例中有11例存在幽门螺杆菌（38%）。与单纯反流性食管炎对照组相比，巴雷特食管患者的幽门螺杆菌性胃窦炎发生率并未增加。巴雷特食管幽门螺杆菌阳性与幽门螺杆菌性胃窦炎的存在相关（P < 0.05），尽管在2例幽门螺杆菌阳性的巴雷特食管病例中，胃窦活检幽门螺杆菌为阴性。幽门螺杆菌阳性和阴性的巴雷特食管在炎症和发育异常变化的严重程度上没有差异。幽门螺杆菌的存在似乎并未改变巴雷特食管的自然病程。
