巴雷特食管患者的幽门螺杆菌感染：一项前瞻性免疫组织化学研究。
Helicobacter pylori infection in patients with Barrett's oesophagus: a prospective immunohistochemical study.
作者信息
Ricaurte O, Fléjou J F, Vissuzaine C, Goldfain D, Rotenberg A, Cadiot G, Potet F
机构信息
Department of Pathology, Bichat-Claude Bernard Hospital, Paris, France.
出版信息
J Clin Pathol. 1996 Feb;49(2):176-7. doi: 10.1136/jcp.49.2.176.
The prevalence of Helicobacter pylori infection in patients with Barrett's oesophagus was studied prospectively. A sensitive immunohistochemical staining of H pylori was performed in oesophageal and gastric biopsies of 73 patients from a surveillance group with this condition. H pylori was detected in 11 cases of Barrett's mucosa (15%) and in 26 gastric mucosa specimens (35.6%). All cases positive in Barrett's mucosa were also positive in the stomach. In Barrett's oesophagus, H pylori was never found on specialised epithelium. The percentage of Barrett's mucosa showing inflammatory changes was similar in specimens with and without H pylori, both for chronic (81% v 79%) and acute (9% v 10%) infiltrates. These results indicate that H pylori infection does not play an aetiological role in Barrett's oesophagus and that colonisation of the metaplastic mucosa by this bacteria is related with the presence of gastric type mucosa in the oesophagus and of H pylori infection in the stomach.
对巴雷特食管患者幽门螺杆菌感染的患病率进行了前瞻性研究。对73例处于监测阶段的此类患者的食管和胃活检组织进行了幽门螺杆菌的敏感免疫组化染色。在11例巴雷特黏膜病例（15%）和26例胃黏膜标本（35.6%）中检测到幽门螺杆菌。巴雷特黏膜中所有呈阳性的病例在胃中也呈阳性。在巴雷特食管中，从未在特化上皮中发现幽门螺杆菌。无论有无幽门螺杆菌，显示炎症变化的巴雷特黏膜百分比在慢性（81%对79%）和急性（9%对10%）浸润方面相似。这些结果表明，幽门螺杆菌感染在巴雷特食管中不发挥病因学作用，并且该细菌在化生黏膜中的定植与食管中胃型黏膜的存在以及胃中幽门螺杆菌感染有关。
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