Akashiba T, Kurashina K, Minemura H, Yamamoto H, Horie T
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo.
Intern Med. 1995 Jun;34(6):528-32. doi: 10.2169/internalmedicine.34.528.
Daytime blood pressure (BP) in 31 male patients with obstructive sleep apnea syndrome (OSAS) was measured and the effects of nasal continuous positive airway pressure (CPAP) treatment on daytime BP were studied. Subjects were 48 +/- 10 (mean +/- SD) years old and weighed 80 +/- 13 kg. The mean systolic BP and diastolic BP were 135 +/- 15 mmHg and 88 +/- 14 mmHg, respectively and daytime hypertension was present in 12 (38%) subjects. Apnea index (AI) and the lowest oxygen saturation during sleep were significantly more severe in the hypertensive (HT) than in the non-hypertensive (NHT) patients (p < 0.05). AI was significantly correlated with diastolic BP (p < 0.05) and the mean and lowest oxygen saturation during sleep were significantly correlated with both systolic (p < 0.05) and diastolic BP (p < 0.01). After nasal CPAP treatment for two weeks, both systolic and diastolic BP were significantly reduced; the former from 135 +/- 15 mmHg to 126 +/- 10 mmHg (p < 0.005) and the latter from 88 +/- 14 mmHg to 78 +/- 6 mmHg (p < 0.001). These data form direct evidence that daytime hypertension is partially induced by OSAS and is reversible with nasal CPAP treatment.
对31例阻塞性睡眠呼吸暂停综合征（OSAS）男性患者的日间血压（BP）进行了测量，并研究了经鼻持续气道正压通气（CPAP）治疗对日间血压的影响。受试者年龄为48±10（平均±标准差）岁，体重80±13kg。平均收缩压和舒张压分别为135±15mmHg和88±14mmHg，12例（38%）受试者存在日间高血压。高血压（HT）患者的呼吸暂停指数（AI）和睡眠期间最低血氧饱和度比非高血压（NHT）患者严重得多（p<0.05）。AI与舒张压显著相关（p<0.05），睡眠期间平均血氧饱和度和最低血氧饱和度与收缩压（p<0.05）和舒张压均显著相关（p<0.01）。经鼻CPAP治疗两周后，收缩压和舒张压均显著降低；前者从135±15mmHg降至126±10mmHg（p<0.005），后者从88±14mmHg降至78±6mmHg（p<0.001）。这些数据构成了直接证据，证明日间高血压部分由OSAS引起，并且经鼻CPAP治疗可逆转。
