Bălan A, Beldescu N, Ghiţescu E, Popa R
Institutul de Igienă, Sănătate Publică, Servicii de Sănătate şi de Conducere-Bucureşti.
Bacteriol Virusol Parazitol Epidemiol. 1995 Apr-Jun;40(2):85-94.
The assessment of the antidiphtheria protection in healthy population is common for a surveillance system within any National Program of Immunization. Our study is intending to measure the antidiphtheria immunity level in apparently healthy peoples living in the southern Romania. Our study were carried out on 8594 healthy subjects. Sample were stratified by nine age groups being representative for the above mentioned area. The titration of diphtheria antitoxin in our laboratory were performed by passive hemagglutination assay (PHA) and in vivo neutralization test (NT). In our study, we had considered as "protective immunity level" an antitoxin titers equal or above 1/640. The overall prevalence of protected peoples was 88.1% (C.I. 95%: 87.4%-88.8%). The prevalence of protected people against diphtheria decrease by age from 94.5% (1-9 years of age) to 82.4% (60 years and over). We think that overall, our national strategy for diphtheria control is quite efficient, but need to be sustained by specific actions concerning some high risk population groups.
在任何国家免疫规划的监测系统中，对健康人群白喉防护情况的评估都是常见的。我们的研究旨在测量罗马尼亚南部看似健康的人群的白喉免疫水平。我们的研究对8594名健康受试者进行。样本按九个年龄组分层，这些年龄组代表上述地区。我们实验室对白喉抗毒素的滴定通过被动血凝试验（PHA）和体内中和试验（NT）进行。在我们的研究中，我们将抗毒素滴度等于或高于1/640视为“保护性免疫水平”。受保护人群的总体患病率为88.1%（95%置信区间：87.4%-88.8%）。对白喉有保护作用的人群患病率随年龄从94.5%（1至9岁）降至82.4%（60岁及以上）。我们认为总体而言，我们国家的白喉控制策略相当有效，但需要针对一些高风险人群群体采取具体行动来加以维持。
