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本文引用的文献

1
Biosynthesis and function of enzymes with covalently bound flavin.具有共价结合黄素的酶的生物合成与功能
Annu Rev Nutr. 1993;13:17-41. doi: 10.1146/annurev.nu.13.070193.000313.
2
Prediction of protein secondary structure at better than 70% accuracy.蛋白质二级结构预测准确率高于70%。
J Mol Biol. 1993 Jul 20;232(2):584-99. doi: 10.1006/jmbi.1993.1413.
3
Issues in searching molecular sequence databases.搜索分子序列数据库中的问题。
Nat Genet. 1994 Feb;6(2):119-29. doi: 10.1038/ng0294-119.
4
Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.蛋白质中保守片段的检测：使用比对模块对序列数据库进行迭代扫描。
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12091-5. doi: 10.1073/pnas.91.25.12091.
5
Production by a baculovirus expression system of the APO-protein of L-gulono-gamma-lactone oxidase, a flavoenzyme possessing a covalently-bound FAD.杆状病毒表达系统生产L-古洛糖酸-γ-内酯氧化酶的脱辅基蛋白，L-古洛糖酸-γ-内酯氧化酶是一种具有共价结合黄素腺嘌呤二核苷酸的黄素酶。
Biochem Mol Biol Int. 1994 May;33(2):313-9.
6
The DIMINUTO gene of Arabidopsis is involved in regulating cell elongation.拟南芥的DIMINUTO基因参与调控细胞伸长。
Genes Dev. 1995 Jan 1;9(1):97-107. doi: 10.1101/gad.9.1.97.
7
A P-loop-like motif in a widespread ATP pyrophosphatase domain: implications for the evolution of sequence motifs and enzyme activity.广泛存在的ATP焦磷酸酶结构域中的类P环基序：对序列基序进化和酶活性的影响。
Proteins. 1994 Dec;20(4):347-55. doi: 10.1002/prot.340200407.
8
Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.淡紫链霉菌中与丝裂霉素C抗性相关的一个基因座（mcr）的克隆与分析
J Bacteriol. 1994 Jul;176(14):4448-54. doi: 10.1128/jb.176.14.4448-4454.1994.
9
Site-directed mutagenesis of the FAD-binding histidine of 6-hydroxy-D-nicotine oxidase. Consequences on flavinylation and enzyme activity.6-羟基-D-尼古丁氧化酶FAD结合组氨酸的定点诱变。对黄素化和酶活性的影响。
FEBS Lett. 1989 Oct 23;257(1):86-8. doi: 10.1016/0014-5793(89)81792-2.
10
Basic local alignment search tool.基本局部比对搜索工具
J Mol Biol. 1990 Oct 5;215(3):403-10. doi: 10.1016/S0022-2836(05)80360-2.

在包括一种参与植物发育的蛋白质在内的一组独特氧化酶中存在一个假定的黄素腺嘌呤二核苷酸（FAD）结合结构域。

A putative FAD-binding domain in a distinct group of oxidases including a protein involved in plant development.

作者信息

Mushegian A R, Koonin E V

机构信息

Department of Microbiology, University of Washington, Seattle 98195, USA.

出版信息

Protein Sci. 1995 Jun;4(6):1243-4. doi: 10.1002/pro.5560040623.

DOI:10.1002/pro.5560040623
PMID:7549889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2143151/
Abstract

Using methods for database screening with individual protein sequences and alignment blocks, a conserved domain is delineated in a group of proteins including several FAD-dependent oxidases. Two motifs within this domain resemble phosphate-binding loops and may be directly involved in FAD binding. These motifs can be readily distinguished from previously described nucleotide-binding sites using a method for database screening with position-dependent weight matrices derived from alignment blocks. Unexpectedly, this group of known and predicted FAD-dependent oxidases includes the product of the DIMINUTO gene, which is involved in Arabidopsis development, and its homologues from man and Mycobacterium leprae.

摘要

利用针对单个蛋白质序列和比对模块进行数据库筛选的方法，在一组包括几种FAD依赖性氧化酶的蛋白质中划定了一个保守结构域。该结构域内的两个基序类似于磷酸结合环，可能直接参与FAD结合。使用针对源自比对模块的位置依赖性权重矩阵进行数据库筛选的方法，可轻松将这些基序与先前描述的核苷酸结合位点区分开来。出乎意料的是，这组已知和预测的FAD依赖性氧化酶包括拟南芥发育相关的DIMINUTO基因的产物及其来自人和麻风分枝杆菌的同源物。