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淡紫链霉菌中与丝裂霉素C抗性相关的一个基因座（mcr）的克隆与分析

Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.

作者信息

August P R, Flickinger M C, Sherman D H

机构信息

Department of Microbiology, University of Minnesota, St. Paul 55108.

出版信息

J Bacteriol. 1994 Jul;176(14):4448-54. doi: 10.1128/jb.176.14.4448-4454.1994.

DOI:10.1128/jb.176.14.4448-4454.1994
PMID:7517396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC205660/
Abstract

Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA shows similarity to sequences of a special class of bacterial, plant, and animal oxygen oxidoreductases.

摘要

从淡紫色链霉菌中鉴定出两个共同赋予丝裂霉素C抗性的基因（mcrA和mcrB）。这段DNA似乎包含一个多顺反子操纵子，带有一个药物诱导型无 leader 的mRNA。mcrA推导的氨基酸序列与一类特殊的细菌、植物和动物氧氧化还原酶的序列相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cc9/205660/452c3d5555ff/jbacter00032-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cc9/205660/02a68fb7793b/jbacter00032-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cc9/205660/452c3d5555ff/jbacter00032-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cc9/205660/02a68fb7793b/jbacter00032-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cc9/205660/452c3d5555ff/jbacter00032-0268-a.jpg

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