淡紫链霉菌中与丝裂霉素C抗性相关的一个基因座（mcr）的克隆与分析
Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.
作者信息
August P R, Flickinger M C, Sherman D H
机构信息
Department of Microbiology, University of Minnesota, St. Paul 55108.
出版信息
J Bacteriol. 1994 Jul;176(14):4448-54. doi: 10.1128/jb.176.14.4448-4454.1994.
Abstract
Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA shows similarity to sequences of a special class of bacterial, plant, and animal oxygen oxidoreductases.
摘要
从淡紫色链霉菌中鉴定出两个共同赋予丝裂霉素C抗性的基因（mcrA和mcrB）。这段DNA似乎包含一个多顺反子操纵子，带有一个药物诱导型无 leader 的mRNA。mcrA推导的氨基酸序列与一类特殊的细菌、植物和动物氧氧化还原酶的序列相似。
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