Wong D W, Eisenman J I, Wade W
Department of Radiology, Los Angeles County King-Charles R. Drew University of Sciences and Medicine, UCLA, School of Medicine 90059, USA.
Nucl Med Biol. 1995 May;22(4):513-9. doi: 10.1016/0969-8051(94)00101-o.
Intact polyvalent human immune globulin (IgG) labeled with Tc-99m by a mild chemical method was investigated with animals infected with either S. aureus or E. coli in the thigh muscle. Focal infection was clearly visualized by Tc-99m IgG scintigraphy within 1 h postinjection. Tc-99m IgG appeared to be concentrated in the liver, spleen, kidneys and urinary bladder. It cleared rapidly via the kidneys resulting minimal of tissue background activity and high infection-to-normal organ ratios. At 24 h postinjection, the ratios of infectious lesion to blood, normal muscle and bone averaged 10:1, 23:1, and 24:1 for S. aureus infection vs 4:1, 9:1 and 9:1 for E. coli infection, respectively. Tc-99m labeled IgG also concentrated in terpentine-induced aseptic inflammatory lesion with a target-to-blood ratio of 4:1, bone 6:1 and normal muscle about 10:1. These findings suggest potential value of Tc-99m IgG as an imaging agent for the early detection of focal infection and inflammation.
采用温和化学方法用锝-99m标记的完整多价人免疫球蛋白（IgG），在感染金黄色葡萄球菌或大肠杆菌的大腿肌肉动物模型中进行了研究。注射后1小时内，通过锝-99m IgG闪烁扫描可清晰观察到局灶性感染。锝-99m IgG似乎集中在肝脏、脾脏、肾脏和膀胱中。它通过肾脏迅速清除，导致组织本底活性极低，感染灶与正常器官的比值很高。注射后24小时，金黄色葡萄球菌感染时，感染病灶与血液、正常肌肉和骨骼的比值分别平均为10:1、23:1和24:1；大肠杆菌感染时分别为4:1、9:1和9:1。锝-99m标记的IgG也集中在松节油诱导的无菌性炎症病灶中，靶与血的比值为4:1，与骨骼的比值为6:1，与正常肌肉的比值约为10:1。这些发现表明锝-99m IgG作为早期检测局灶性感染和炎症的显像剂具有潜在价值。
