Wong D W, Mandal A
Department of Radiology, Los Angeles County Martin Luther King Hospital, Los Angeles, CA, USA.
Nucl Med Biol. 1996 May;23(4):473-8. doi: 10.1016/0969-8051(96)00024-8.
The efficacy of Tc-99m-labeled intact polyvalent human immune globulin (IgG) for the early localization and detection of acute appendicitis was evaluated by an animal model. Acute appendicitis was surgically produced in adult Sprague-Dawley white rats by ligating a 3-cm segment of the caecum and inoculating with E. coli. After 4-5 days, nuclear scintigraphy was performed following intravenous injection of 5 mCi of Tc-99m IgG via the tail vein. Appendiceal and colonic infections were clearly visualized by Tc-99m IgG scans within 30 min postinjection and confirmed by autopsy and tissue distribution data. With the exception of the liver, the kidneys, and the urinary bladder, abdominal tissue background activity was minimal. These findings suggest that Tc-99m-labeled intact IgG may have potential clinical application in the early detection and diagnosis of acute appendicitis in emergency medicine.
通过动物模型评估了锝-99m标记的完整多价人免疫球蛋白（IgG）在急性阑尾炎早期定位和检测中的功效。通过结扎3厘米长的盲肠段并接种大肠杆菌，在成年斯普拉格-道利白色大鼠中手术制造急性阑尾炎。4至5天后，经尾静脉静脉注射5毫居里的锝-99m IgG后进行核闪烁扫描。注射后30分钟内，锝-99m IgG扫描清晰显示阑尾和结肠感染情况，并经尸检和组织分布数据证实。除肝脏、肾脏和膀胱外，腹部组织本底活性极小。这些发现表明，锝-99m标记的完整IgG在急诊医学中急性阑尾炎的早期检测和诊断方面可能具有潜在的临床应用价值。
