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[去垂体术及弱交变磁场作用导致大鼠血液淋巴细胞中脱氢酶的亚日节律变化]

[Changes in the infradian rhythm of the dehydrogenases in the blood lymphocytes of rats due to epiphysectomy and the action of weak alternating magnetic fields].

作者信息

Temur'iants N A, Shekhotkin A V

出版信息

Aviakosm Ekolog Med. 1995;29(3):39-43.

PMID:7550167
Abstract

In experiments with 110 white inbred male rats, the infradian rhythm changes in succinate- and alpha-glycerophosphate dehydrogenases in rat's lymphocytes due to epiphysectomy, exposure to transitory magnetic field (TrMF) at 8 Hz and 5 microTl, and their combined effect were studied. According to spectral analysis, the infradian rhythms of lymphocyte succinate dehydrogenase, alpha-glycerophosphate dehydrogenase mean activities in intact animals amounted to 26.5 +/- 2.5; 19.1 +/- 1.1; 13.5 +/- 1.1; 9.1 +/- 0.8; 6.9 +/- 0.7; 3.6 +/- 0.2 days. Epiphysectomy decreases the observed rhythm amplitudes, shifts phases, disrupts temporal organization of the redox processes, i.e., induces desynchronosis. TrPM at 8 Hz also causes desyncronosis in intact animals though less pronounced than in epiphysectomized rats. TrMP partially normalizes temporal organization of the dehydrogenase status in epiphysectomized rats. Our findings point to the possibility to apply TrMF for "functional epiphysectomy" of intact animals and, in case of desynchronoses, as biorhythm "time sensors".

摘要

在对110只白色近交系雄性大鼠进行的实验中,研究了大鼠淋巴细胞中琥珀酸脱氢酶和α - 甘油磷酸脱氢酶的次昼夜节律变化,这些变化是由于去垂体、暴露于8Hz和5μT的瞬变磁场(TrMF)及其联合作用引起的。根据频谱分析,完整动物淋巴细胞琥珀酸脱氢酶、α - 甘油磷酸脱氢酶平均活性的次昼夜节律分别为26.5±2.5;19.1±1.1;13.5±1.1;9.1±0.8;6.9±0.7;3.6±0.2天。去垂体降低了观察到的节律幅度,使相位发生偏移,破坏了氧化还原过程的时间组织,即诱发了失同步。8Hz的TrPM在完整动物中也会导致失同步,但其程度比去垂体大鼠轻。TrMP可部分使去垂体大鼠脱氢酶状态的时间组织恢复正常。我们的研究结果表明,TrMF有可能用于完整动物的“功能性去垂体”,并且在出现失同步的情况下,可作为生物节律的“时间传感器”。

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