Pishak V P, Kokoshchuk H I
Fiziol Zh (1994). 1995 Sep-Dec;41(5-6):23-6.
Epiphysectomy in adult pubescent Wistar rats causes polyuria and Na uresis at the expense of the increased rate of the glomerular filtration and sodium filtration charge. Melatonin in a dose of 4.31 mkM/100 g of the body weight increased the glomerular filtration of both sodium and water and stimulated the sodium tubular transport in rats with intact epiphysis and did not normalize changes of the nephron excretory activity after epiphysectomy.
对成年青春期Wistar大鼠进行骺板切除术会导致多尿和钠尿,代价是肾小球滤过率和钠滤过负荷增加。剂量为4.31 mkM/100 g体重的褪黑素增加了钠和水的肾小球滤过,并刺激了具有完整骨骺的大鼠的肾小管钠转运,但并未使骺板切除术后肾单位排泄活动的变化恢复正常。