Smirnova O A
Aviakosm Ekolog Med. 1995;29(3):45-9.
The mathematical models describing the dynamics of hemopoiesis in the mammals exposed to a combination of chronic irradiation are devised and studied. The models reproduce the increased radiosensitivity of the systems of thrombocytopoiesis, erythropoiesis and lymphopoiesis in the animals resulting from prolonged radiation exposure. Succeeding acute radiation exposure causes a more severe damage of the above-mentioned systems than it occurs for the species not being previously exposed to radiation. The model of granulocytopoiesis simulates both the decrease and the increase in radiosensitivity of this system due to the effect of chronic exposure using low and somewhat higher radiation doses, respectively. The postchronic acute radiation exposure has respectively the decreased or increased damaging effect. Within the limits of the models an interpretation of these effects is suggested. The results of modelling have an important theoretical significance in studies of the mechanisms of an effect of small doses of radiation on the mammalian organism as well as point to the perspectives of simulation experiments when evaluating the real radiation risks during long-term space missions.
设计并研究了描述暴露于慢性辐射组合下的哺乳动物造血动力学的数学模型。这些模型再现了动物因长期辐射暴露而导致的血小板生成、红细胞生成和淋巴细胞生成系统放射敏感性增加的情况。后续的急性辐射暴露对上述系统造成的损伤比未预先暴露于辐射的物种更为严重。粒细胞生成模型分别使用低剂量和稍高剂量的辐射，模拟了由于慢性暴露的影响，该系统放射敏感性的降低和增加。慢性辐射后的急性辐射暴露分别具有降低或增加的损伤作用。在模型范围内，对这些效应提出了解释。建模结果在研究小剂量辐射对哺乳动物机体的作用机制方面具有重要的理论意义，同时也指出了在评估长期太空任务中的实际辐射风险时进行模拟实验的前景。
