Burkovskaia T E, Shafirkin A V, Petrov V M, Shtemberg A S, Chel'naia N A, Ivanova S M
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):33-41.
The article is dedicated to comparison of the biological effectiveness of continuous and fractionated gamma-irradiation of rhesus macaques by equally effective doses. These radiation conditions are broadly used in radiobiological experiments. Specifically, they are applied in modeling radiation effects on cosmonauts during extended exploration mission. A model of radiation damage and repair on the cell, tissue and organism levels, i.e., a model of effective residual dose responsible for change in mammals' resistance to irradiation of varying duration was used to calculate equally effective doses in the experiment with primates subject to continuous and fractionated exposure. The authors publish data related to formation of radiation lesion and rate of ensuing hemopoiesis reparation. Two groups of animals were compared in resistance modification followed after testing by acute irradiation. The test was to reproduce a radiation situation for cosmonauts in the event of a cannonade of powerful solar proton events resulting in an effective residual dose of 1 Sv total The experiment evidenced close resemblance of the hemopoietic effects in primates exposed to the compared radiation conditions.
本文致力于比较恒河猴在同等有效剂量下接受连续和分次伽马辐射的生物效应。这些辐射条件在放射生物学实验中被广泛使用。具体而言，它们被应用于模拟长期探索任务期间辐射对宇航员的影响。在对灵长类动物进行连续和分次照射的实验中，使用了细胞、组织和生物体水平的辐射损伤和修复模型，即负责改变哺乳动物对不同持续时间照射抵抗力的有效残余剂量模型，来计算同等有效剂量。作者公布了与辐射损伤形成及随后造血修复速率相关的数据。在急性照射测试后，比较了两组动物在抗性改变方面的情况。该测试旨在重现强大太阳质子事件炮击导致总有效残余剂量为1 Sv时宇航员的辐射情况。实验证明，暴露于所比较辐射条件下的灵长类动物的造血效应非常相似。
