Payne L G, Jenkins S A, Andrianov A, Roberts B E
Virus Research Institute, Inc., Cambridge, Massachusetts 02138, USA.
Pharm Biotechnol. 1995;6:473-93. doi: 10.1007/978-1-4615-1823-5_20.
PCPP can be used in two different ways to potentiate an immune response. The soluble form of the polymer has been found to have immunoadjuvant activity. A single subcutaneous injection of polymer/influenza dramatically increases the ELISA, neutralizing, and HI antibodies to influenza virus compared to CFA. The polymer has also succeeded in dramatically increasing the amount of ELISA antibodies to TT. The antibody response elicited was predominantly of the IgG1 isotype. PCPP has also been used to generate micron-sized hydrogel microspheres through a process of divalent ion cross-linking of the polymer strands. These microspheres can induce significantly higher anti-TT serum IgG titers after a single intranasal immunization than TT alone.
PCPP可通过两种不同方式用于增强免疫反应。已发现该聚合物的可溶形式具有免疫佐剂活性。与弗氏完全佐剂相比，单次皮下注射聚合物/流感疫苗可显著提高针对流感病毒的ELISA、中和及血凝抑制抗体水平。该聚合物还成功显著提高了针对破伤风类毒素的ELISA抗体量。引发的抗体反应主要为IgG1同种型。PCPP还通过聚合物链的二价离子交联过程用于生成微米级水凝胶微球。与单独使用破伤风类毒素相比，这些微球在单次鼻内免疫后可诱导显著更高的抗破伤风类毒素血清IgG滴度。
